Overview

protein kinase R


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(PKR)

A serine/threonine protein kinase (eukaryotic translation initiation factor 2α kinase 2, 551 aa) that is activated by viral double-stranded RNA which causes it to autophosphorylate and to inhibit protein synthesis in the cell. It is induced by interferon and is part of the antiviral defence mechanism.

Subjects: Medicine and Health.


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