protein zero

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A transmembrane protein (myelin protein zero, 248 aa), synthesized by Schwann cells, that constitutes ~50% of the total protein in the myelin sheath of peripheral nerves. Mutations in the MPZ gene that encodes it are associated with the autosomal dominant form of Charcot–Marie–Tooth disease type 1 (CMT1), Dejerine–Sottas syndrome, congenital hypomyelinating neuropathy, and several types of axonal CMT2.

Subjects: Medicine and Health.

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