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A protein (zinc finger FYVE domain-containing protein-27, ZFYVE27, 404 aa) that promotes neurite formation by regulating directed membrane trafficking. Phosphorylation of protrudin in response to nerve growth factor promotes its association with Rab11-GDP. Mutation is associated with autosomal dominant hereditary spastic paraplegia type 33 (SPG33). Protrudin interacts with spastin and the chaperone FKBP38.

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