An active transport mechanism that uses ATP to move hydrogen ions across a lipid bilayer. The F-type ATPases can also run in reverse to synthesize ATP (‘ATP synthase’). The V-type ATPases are found in intracellular vesicles with an acidic lumen, and on certain epithelial cells (e.g. kidney intercalated cells). Another example is the H+,K+-ATPase involved in secretion of gastric acid, the target for proton pump inhibitors.
Subjects: Medicine and Health.