A class of voltage-sensitive calcium channels (CaV2.1, CACNA1A) that are found in various neurons but especially in Purkinje cells of the cerebellum. They require substantial depolarization to activate and are slow to inactivate. The α1A subunit forms the pore and the beta, gamma, and delta subunits have regulatory functions. Mutations are associated with episodic ataxia-2, familial hemiplegic migraine, spinocerebellar ataxia-6, and idiopathic generalized epilepsy. They are inhibited by agatoxin and a polyamine FTX, through a G-protein-coupled mechanism.
Subjects: Medicine and Health.