Overview

5q– syndrome


Show Summary Details

Quick Reference

A myelodysplasia characterized by a defect in erythroid differentiation in which there is a deletion of the long arm of chromosome 5 containing ˜40 genes. The key deletion is that for the gene encoding ribosomal subunit protein RPS14, although several genes encoding cytokines or their receptors have been mapped to this region (αFGF, GM-CSF, IL-3, IL-4, IL-5, IL-9, both subunits of IL-12, the gene encoding IRF1 (interferon regulatory factor-1) and the genes encoding the receptor for M-CSF and PDGF, and the FGF receptor, FGFR4).

Subjects: Medicine and Health.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.