Powerful Meccan tribe at the time of the Prophet Muhammad; descendants of Qusayy, who united them. The Quraysh were prosperous merchants controlling Mecca and trade in the region. Muhammad was born into the Hashemite clan of the Quraysh tribe. Presently the keys to the Kaaba are held by the Quraysh clan. Surah 106 in the Quran is directed at them.