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RAD


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The symbol for a gene that repairs radiation damage to DNA. In Schizosaccharomyces pombe there are four Rad genes that are involved at DNA damage checkpoints (q.v.). The wild-type allele of rad3 encodes a protein called a phosphatidylinositol 3-kinase (Pl 3-kinase). This enzyme transduces signals from the environment that detect damage to DNA. The normal allele of a gene in humans that is responsible (when mutated) for the hereditary disease ataxia-telangiectasia encodes a homologous Pl 3-kinase. See ATM kinase.

Subjects: Genetics and Genomics.


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