An experimentally produced animal containing hemopoeitic cells of a genotype different from that of the rest of the organism. Recipients receive a single dose of radiation that kills the stem cells of the bone marrow and much of the differentiated hemopoeitic tissue. Very shortly thereafter, they receive an intravarious inoculation of bone marrow or fetal liver cells from nonirradiated donors. The injected stem cells home to the recipient's bone marrow sites and begin repopulating them, and ultimately they replace the recipient's hemopoeitic tissues.
Subjects: Genetics and Genomics.