An oncogene (v-raf), originally identified in a murine sarcoma virus, that encodes a serine/threonine kinase (EC 18.104.22.168, 648 aa). In humans Raf-1 is ubiquitously expressed, whereas A-Raf is predominantly found in urogenital tissue and B-Raf shows the highest expression in neural tissue and testis. All three forms can be activated by GTP-*ras and phosphorylate MEK, though their potency differs. Mutations in BRAF are associated with various tumours, including melanomas, carcinomas, lymphomas, and also cardiofaciocutaneous syndrome. The mil oncogene is the avian equivalent of the murine raf oncogene. See Noonan's syndrome.
Subjects: Medicine and Health.