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n. an antiretroviral (ARV) drug used, in combination with other ARVs, for treating refractory HIV infection. It acts by inhibiting integrase, an enzyme required by the virus to replicate and infect other cells. It is administered by mouth; side-effects include abdominal pain, constipation, and lipodystrophy. Trade name: Isentress.

Subjects: Clinical Pharmacology and Therapeutics.

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