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RAS protein


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'RAS protein' can also refer to...

RAS protein

RAS protein

Ras protein

The Undruggable RAS Protein

Dexamethasone-induced Ras-related protein 1 is a potential regulatory protein in B lymphocytes

A method for computational combinatorial peptide design of inhibitors of Ras protein

Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction

Specific distribution in homobasidiomycete hymenophores of the transcripts of Ras protein and G-protein α-subunit genes

The actin-based motility of intracellular Listeria monocytogenes is not controlled by small GTP-binding proteins of the Rho- and Ras-subfamilies

Roles of the three Ras proteins in the regulation of dimorphic transition in the yeast Yarrowia lipolytica

Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics.

RasGTPase-activating protein is a target of caspases in spontaneous apoptosis of lung carcinoma cells and in response to etoposide

The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-α signalling in cardiomyocytes

Age-Related Decline in Ras/ERK Mitogen-Activated Protein Kinase Cascade Is Linked to a Reduced Association Between Shc and EGF Receptor

Oxidized low density lipoproteins stimulate galactosyltransferase activity, ras activation, p44 mitogen activated protein kinase and c-fos expression in aortic smooth muscle cells

Modulation of the expression of the rabbit galectin-3 gene by p53 and c-Ha-ras proteins and PMA

MP009THE EFFECT OF RENIN-ANGIOTENSIN SYSTEM (RAS) ON ENDOTHELIAL PERMEABILITY AND PLASMALEMMA VESICLE ASSOCIATED PROTEIN (PV-1) EXPRESSION IN VITRO

Human DNA helicase VIII: A DNA and RNA helicase corresponding to the G3BP protein, an element of the Ras transduction pathway

Adaptation of the Ras‐recruitment system to the analysis of interactions between membrane‐associated proteins

 

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A small G protein that functions in cells as a molecular switch in signal transduction pathways regulating cell growth and other activities. In its active state it binds the nucleotide guanosine triphosphate (GTP), but because RAS has intrinsic GTPase activity, the GTP is rapidly converted to GDP, thereby returning RAS to its inactive state. Activation of RAS is mediated by a guanine-nucleotide exchange factor (GEF). When a surface receptor is activated, GEF transiently displaces GDP from RAS, enabling it to bind GTP. RAS exerts its effects by activating a cascade of sequentially activating protein kinases, including MAP kinase, which ultimately regulates gene expression. RAS is encoded by the proto-oncogene RAS in humans, which is homologous to the rodent oncogene ras (named after rat sarcoma, and also found in a retrovirus). A gene mutation involving a single base change (G → T) is sufficient to transform the normal protein into an oncoprotein, which lacks the intrinsic GTPase activity and is permanently activated. It is associated with many human tumours.

Subjects: Biological Sciences.


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