The product of the RecA locus of E. coli. The protein is of great antiquity, since it occurs in virtually all bacteria. The RecA monomer contains 352 amino acids. The monomers are packed to form a continuous right-handed spiral with six monomers per turn of the helix. The spiral filament contains a deep groove that can accommodate up to three strands of DNA. The RecA protein is a DNA-dependent ATPase, and ATP is hydrolyzed during genetic recombination processes. See Chronology, 1965, Clark; 1992, Story, Weber, and Steitz.
Subjects: Genetics and Genomics.