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A calcium-binding protein (cancer-associated retinopathy, CAR, p26, RCVRN, RCV1, 200 aa), one of a family of neuronal calcium sensors that mediates the recovery of the dark current after photoactivation in the retina. Calcium causes a myristoyl group to move away from a binding pocket and allows new protein–protein interactions (calcium-myristoyl switch). NB Recoverin is no longer thought to be an activator of photoreceptor guanylate cyclase. It may be the antigen involved with cancer-associated retinopathy. Other members of the recoverin family are visinin, hippocalcin, neurocalcin, S-modulin, visinin-like protein, and frequenin.

http://nmr.uhnres.utoronto.ca/ikura/1008/calcium/recoverin/recoverin.html Further information about recoverin and its role in vision.

Subjects: Medicine and Health — Chemistry.

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