representational difference analysis

'representational difference analysis' can also refer to...

representational difference analysis (RDA)

representational difference analysis

Isolation of rare transcripts by representational difference analysis

Identification of genomic differences between Cryptococcus neoformans and Cryptococcus gattii by Representational Difference Analysis (RDA)

Identification of Brachyspira hyodysenteriae-specific DNA fragments using representational difference analysis

Use of representational difference analysis to identify Escherichia coli O157-specific DNA sequences

Representational difference analysis uncovers a novel IS10-like insertion element unique to pathogenic strains of Yersinia enterocolitica

Representational difference analysis of Neisseria meningitidis identifies sequences that are specific for the hyper-virulent lineage III clone

Representational difference analysis in a lupus-prone mouse strain results in the identification of an unstable region of the genome on chromosome 11

Detection of homozygous deletions in tumors by hybridization of representational difference analysis (RDA) products to chromosome-specific YAC clone arrays

Identification of fragments of human transcripts from a defined chromosomal region: representational difference analysis of somatic cell hybrids

Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization

Species-independent detection of RNA virus by representational difference analysis using non-ribosomal hexanucleotides for reverse transcription


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A technique used to detect DNA segments in one sample (the tester pool) that are not in another (the driver pool). DNAs from each pool are fragmented by digestion with restriction endonucleases (q.v.), and the fragments are amplified by the polymerase chain reaction (q.v.). The amplicons from one pool are then allowed to hybridize with those from the other, and the hybrid molecules are removed. This subtractive hybridization leads to the enrichment of fragments that are unique to the tester pool. Such a technique could be used to isolate cDNAs from genes specifically activated by certain hormones.

Subjects: Genetics and Genomics.

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