Proteins involved in DNA replication. Replication factor A (replication protein A) is a heterotrimeric single-stranded-DNA-binding protein (subunits p70, 616 aa; p32, 270 aa; p14, 121 aa) that associates, together with the kinase ATM, at sites where homologous regions of DNA interact during meiotic prophase and at breaks associated with meiotic recombination. It is essential for replication of SV40 virus. Replication factor C (activator 1) is a five-subunit accessory protein (clamp loader) that loads, in an ATP-dependent manner, various components of the DNA replicating machinery at the replication fork. and interacts with proliferating cell nuclear antigen (PCNA).
Subjects: Medicine and Health.