RE1-silencing transcription factor

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A transcriptional repressor (REST, neuron-restrictive silencer factor, 1097 aa) that represses neuronal genes in non-neuronal tissues by binding to the neuron-restrictive silencer element. Also blocks the expression of an miRNA (miR-21) that prevents embryonic stem cells from reproducing themselves and causes them to differentiate into specific cell types.

Subjects: Medicine and Health.

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