A family of nuclear receptors involved in many pathophysiological processes such as cerebellar ataxia, inflammation, atherosclerosis, and angiogenesis. RORα (RORA, 468 aa) may regulate production of a bone matrix component. RORβ (RORB, 459 aa) shows a marked circadian rhythm of expression in the brain and may be involved with clock-related functions. RORγ (RORG, 560 aa) is expressed at highest level in skeletal muscle and also in T cells where it seems that the decision of antigen-stimulated cells to differentiate into either Th17 or Treg cells depends on the cytokine-regulated balance of RORγ and FOXP3.
Subjects: Medicine and Health.