retinoic acid receptor related orphan receptor

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A family of nuclear receptors involved in many pathophysiological processes such as cerebellar ataxia, inflammation, atherosclerosis, and angiogenesis. RORα (RORA, 468 aa) may regulate production of a bone matrix component. RORβ (RORB, 459 aa) shows a marked circadian rhythm of expression in the brain and may be involved with clock-related functions. RORγ (RORG, 560 aa) is expressed at highest level in skeletal muscle and also in T cells where it seems that the decision of antigen-stimulated cells to differentiate into either Th17 or Treg cells depends on the cytokine-regulated balance of RORγ and FOXP3.

Subjects: Medicine and Health.

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