n. the rapid breakdown of skeletal muscle cells, with the release of myoglobin and other potentially toxic cell components. Blood levels of creatine kinase are raised. It can result in hyperkalaemia, hypovolaemia, myoglobinuric acute renal failure, and disseminated intravascular coagulation. Causes include muscle trauma and crush injury, alcohol abuse, seizures, and medications (notably statins).
Subjects: Medicine and Health.