rhodopsin kinase

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A G-protein dependent receptor kinase (GRK1, 564 aa) that mediates rapid desensitization of rod photoreceptors to light by phosphorylating rhodopsin which is then bound by cytosolic arrestin, and uncoupled from transducin. See recoverin. Some forms of Oguchi's disease, a recessively inherited form of stationary night blindness, are due to defects in GRK1, others to mutations in the arrestin gene.

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