rho kinases

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'rho kinases' can also refer to...

rho kinases

Rho-kinase, the forgotten link?

The RhoA/Rho kinase pathway in the myocardium

Increased Rho kinase activity in congestive heart failure

Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation

Rho/Rho-kinase and C-reactive protein relationship in hypertension and atherosclerosis

Interleukin-17 causes Rho-kinase-mediated endothelial dysfunction and hypertension

Expression and modulation of Rho kinase in human pregnant myometrium

The Rho(ad)-kinase for individualized treatment of vasospastic angina

Enhancement of Rho/Rho-kinase system in regulation of vascular smooth muscle contraction in tachycardia-induced heart failure

Postnatal maturational shift from PKCζ and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction

Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway

O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway

Critical role of Rho-kinase pathway for cardiac performance and remodeling in failing rat hearts

Circumferential stretching of saphenous vein smooth muscle enhances vasoconstrictor responses by Rho kinase-dependent pathways

Androgens potentiate renal vascular responses to angiotensin II via amplification of the Rho kinase signaling pathway

Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats

Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury☆

Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase


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Serine/threonine kinases (ROCKs) that are activated when bound to GTP-rho and are involved in effecting rho-mediated control of stress fibres and focal adhesions by phosphorylating and and activating LIM kinase. Abnormal activation of the rhoA/ROCK pathway may be important in cardiovascular disorders. A selective inhibitor, fasudil, has been reported. ROCK2 (1388 aa) is an isozyme of ROCK1 (1354 aa).

Subjects: Medicine and Health.

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