Serine/threonine kinases (ROCKs) that are activated when bound to GTP-rho and are involved in effecting rho-mediated control of stress fibres and focal adhesions by phosphorylating and and activating LIM kinase. Abnormal activation of the rhoA/ROCK pathway may be important in cardiovascular disorders. A selective inhibitor, fasudil, has been reported. ROCK2 (1388 aa) is an isozyme of ROCK1 (1354 aa).
Subjects: Medicine and Health.