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An inwardly-rectifying ATP-dependent potassium channel (renal outer medullary potassium channel, Kir1.1, KCNJ1) that transports potassium out of cells and is expressed in the thick ascending limb of Henle and throughout the distal nephron of the kidney. Mutations lead to antenatal Bartter's syndrome type 2 and decrease the strength of channel-PIP2 interactions which are important for normal function.

Subjects: Medicine and Health.

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