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A family of transmembrane proteins involved in the dystrophin-associated protein complex and that, together with dystrophin, dystroglycans, and syntrophins, link the contractile system of muscle to extracellular matrix. At least six sarcoglycans are known including α-sarcoglycan (50DAG, A2, adhalin, 387 aa), β-sarcoglycan (43DAG; A3b), and γ-sarcoglycan (35DAG; A4). Mutations in sarcoglycan genes are responsible for some forms of muscular dystrophy.

Subjects: Chemistry — Medicine and Health.

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