Overview

SCAP


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A membrane protein (SREBP cleavage-activating protein, 1277 aa) that escorts SREBPs from the endoplasmic reticulum to the Golgi, where they are cleaved by site-1 protease to release their transcription factor domain which activates genes for lipid synthesis. If sterols are present this transport is blocked, providing a feedback control for lipid synthesis.

Subjects: Medicine and Health.


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