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Scatchard plot


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A graphical method for analysing reversible ligand/receptor binding interactions. The plot of (bound ligand/free ligand) against (bound ligand) gives a line with a slope that is the negative reciprocal of the binding affinity and an intercept on the x-axis that is the number of receptors (at infinite ligand concentration bound/free becomes zero). The Scatchard plot is better than the Eadie–Hoffstee plot for binding data because it depends more on the values at high ligand concentration, the most reliable values. Nonlinearity can arise through heterogeneity of receptors, although there are other possible causes.

Subjects: Chemistry — Medicine and Health.


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