Schizosaccharomyces pombe

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A fungus that can vary in shape from single globose to cylindrical cells that reproduce by septal fission (q.v.). A mitotic spindle forms during G2, and the chromosomes condense. However, the nuclear envelope remains intact. S. pombe can also form true hyphae (q.v.). Sexual reproduction results when haploid cells fuse to produce a zygote. This undergoes meiosis to form an ascus that contains four haploid ascospores. These develop into vegetative cells. Its genome contains 12.5 × 106 bp of DNA. Comparison of the genes of Saccharomyces cerevisiae (q.v.) and Schizosaccharomyces pombe has revealed that genes of the latter are far more likely to contain introns than those from Saccharomyces. S. pombe is a favorite for the study of the genetic regulation of the progression through the cell cycle. See Classification, Fungi, Ascomycota; Chronology, 1976, Nurse, Thuriaux and Nasmyth; 1994, Chikashige et al.

Subjects: Genetics and Genomics — Chemistry.

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