A bone morphogenic protein (BMP) antagonist (213 aa), the gene for which is mutated in sclerosteosis and down-regulated in van Buchem's disease. Sclerostin apparently represses BMP-induced osteoblast differentiation and function. Sclerostin has a cystine knot motif (residues 80–167) similar to that in the cer/dan family of secreted glycoproteins, which are antagonists of members of the TGFβ superfamily. Sclerostin is inactivated by noggin. Sclerostin-domain containing protein1 (ectodin, 206 aa) inhibits BMP2, BMP4, BMP6, and BMP7.
Subjects: Medicine and Health.