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sclerostin


'sclerostin' can also refer to...

sclerostin

Serum Sclerostin in Alcoholics: A Pilot Study

SP558SCLEROSTIN; ANOTHER VASCULAR CALCIFICATION INHIBITOR

P-09SERUM SCLEROSTIN AND CARDIOVASCULAR RISK FACTORS IN ALCOHOLICS

SP616CARDIOVASCULAR STRATIFICATION BY PLASMA SCLEROSTIN IN DIALYSIS PATIENTS

Sclerostin in CKD-MBD: one more paradoxical bone protein?

Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin

Independent association between serum sclerostin levels and carotid artery atherosclerosis in prevalent haemodialysis patients

MP350VITAMIN D RECEPTOR ACTIVATION INCREASES SERUM SCLEROSTIN IN CKD PATIENTS: A RANDOMIZED CLINICAL TRIAL

MP259GLYCOPROTEIN SCLEROSTIN AND VASCULAR CALCIFICATION IN PATIENTS WITH CHRONIC KIDNEY DISEASE

SP484RELATIONSHIP BETWEEN SCLEROSTIN AND CARDIOVASCULAR CALCIFICATION IN MAINTENANCE HEMODIALYSIS PATIENTS

MP578INCREASED PLASMA SCLEROSTIN CONCENTRATION IN HEMODIALYSIS PATIENTS WITH SECONDARY HYPERPARATHYROIDISM TREATED WITH CINACALCET

Osteoprotegerin and sclerostin in chronic kidney disease prior to dialysis: potential partners in vascular calcifications

Rat-Specific Decreases in Platelet Count Caused by a Humanized Monoclonal Antibody Against Sclerostin

Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients

Sclerostin: another bone-related protein related to all-cause mortality in haemodialysis?

Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats

Switching from tenofovir to abacavir in HIV-1-infected patients with low bone mineral density: changes in bone turnover markers and circulating sclerostin levels

E53. Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Bone Mineral Density, Disease Activity and Radiological Grading

 

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A bone morphogenic protein (BMP) antagonist (213 aa), the gene for which is mutated in sclerosteosis and down-regulated in van Buchem's disease. Sclerostin apparently represses BMP-induced osteoblast differentiation and function. Sclerostin has a cystine knot motif (residues 80–167) similar to that in the cer/dan family of secreted glycoproteins, which are antagonists of members of the TGFβ superfamily. Sclerostin is inactivated by noggin. Sclerostin-domain containing protein1 (ectodin, 206 aa) inhibits BMP2, BMP4, BMP6, and BMP7.

Subjects: Medicine and Health.


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