Overview

secretase


Related Overviews

 

'secretase' can also refer to...

secretase

secretases

gamma-secretase

alpha-secretase

beta-secretase

α‐secretase

Molecular mechanism of intramembrane proteolysis by γ-secretase

Structural Features of Human Memapsin 2 (β-Secretase) and their Biological and Pathological Implications

Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects

Phosphatidylethanolamine plasmalogen enhances the inhibiting effect of phosphatidylethanolamine on γ-secretase activity

A reporter for amyloid precursor protein γ-secretase activity in Drosophila

Modulation of beta-secretase gene expression by action of catalytic nucleic acids

Thimet Oligopeptidase Cleaves the Full-Length Alzheimer Amyloid Precursor Protein at a β-Secretase Cleavage Site in COS Cells

Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts

Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability

 

More Like This

Show all results sharing these subjects:

  • Medicine and Health
  • Chemistry

GO

Show Summary Details

Quick Reference

A family of peptidases involved in processing of membrane-bound precursor molecules. α-Secretase (ADAM10, EC 3.4.24.81, 748 aa) cleaves amyloid precursor protein (APP) to produce the soluble nonamyloidogenic product sAPPα; this prevents the formation of amyloid (beta peptide. It also has TNF-convertase activity. (Beta-Secretase (BACE-1, beta-site APP cleaving enzyme 1, EC 3.4.23.46, 501 aa) is an integral membrane aspartic peptidase that generates the N-terminus of the β-amyloid protein from APP. Further cleavage is then carried out by γ-secretase, a multiprotein complex responsible for the intramembranous cleavage of the amyloid precursor protein (APP) and other type I transmembrane proteins such as notch and E-cadherin. There are four components, presenilin, nicastrin, APH-1, and PEN-2, all of which are required for activity; a fifth component, CD147, seems to have a regulatory role. Mutations in presenilin are a risk factor for Alzheimer's disease.

Subjects: Medicine and Health — Chemistry.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.