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selective (o)estrogen receptor modulator


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(SERM) a drug that has oestrogen-like activity in some tissues and an anti-oestrogenic effect in others, depending on the manner of its binding with the oestrogen receptors. Tamoxifen was the first SERM to be introduced. Because of its activity as an anti-oestrogen it is used in the treatment of breast cancer, but its oestrogenic activity may cause side-effects. Raloxifene is used in the treatment of osteoporosis for its oestrogenic effects on bone density.

Subjects: Medicine and Health.


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