A family of cytoplasmic cytoskeletal filament-forming proteins (~350 aa) with a conserved GTP-binding domain. They were first identified in the ring of 10-nm filaments that forms where daughter cells are budded off in Saccharomyces cerevisiae, but homologues are found associated with the cleavage furrow in insects and vertebrates. Various septins are involved in membrane dynamics, vesicle trafficking, apoptosis, and cytoskeletal remodelling and there are at least twelve human septins. Septin-7 interacts with CENP-E at the kinetochore. Mutations in septin-9 are associated with hereditary neuralgic amyotrophy.
Subjects: Medicine and Health.