sequence similarity estimates

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Conclusions made from nucleotide by nucleotide comparison of DNA segments from species that have diverged only recently. For example, when the class 1 segments of the major histocompatibility complexes (MHC) (q.v.) of man and chimpanzee were compared, nucleotide substitutions were found less often than insertions and deletions (indels). This was unexpected, since it was always assumed that indels were more difficult to generate than base substitutions. See Chronology, 2003, Anzai et al.

Subjects: Genetics and Genomics.

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