Serratia marcescens

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A Gram-negative bacterium that is common in soil and water but is an opportunistic pathogen, increasingly a problem with the emergence of antibiotic resistance. Most strains produce a characteristic red pigment, prodigiosin. Serratia marcescens haemolysin is a pore-forming toxin quite distinct from other pore-forming toxins (e.g. RTX toxins). It is a heterodimer of ShlB and ShlA that is activated by a conformational change that requires phosphatidylethanolamine as a cofactor.

Subjects: Medicine and Health.

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