Serine/threonine protein kinases (SGKs) that are transcriptionally regulated by corticoids, serum, and cell volume. Alternatively spliced variants, under separate promoters, have been identified. Sgk1 (431 aa) regulates epithelial ion transport by phosphorylating and inactivating Nedd4–2, an E3 ubiquitin-protein ligase that targets the epithelial Na+ channel (ENaC) and the excitatory amino acid transporter (EAAT)2 for degradation. The latter may account for the role of SGK in facilitating spatial learning in rats. SGKs are related to Akt (PKB).
Subjects: Medicine and Health.