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A gene in yeast that is similar in base sequence to the human gene that causes Werner syndrome (q.v.). In both species, mutations at this locus speed up aging. In mutant yeast cells there is an excessive production of small circles of ribosomal DNA. Eventually the rDNA exceeds the amounts of DNA that comprise the total genome in the normal yeast cell. See gene amplification.

Subjects: Genetics and Genomics.

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