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shiga toxin


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A toxin (verotoxin) from Shigella dysenteriae. Shiga toxin and the shiga-like toxins (SLTs) are structurally related AB toxins with a pentameric B subunit that binds globotriaosylceramide. The A subunit is internalized and cleaved into two parts and the A1 component then binds to the ribosome, disrupting protein synthesis.

Subjects: Medicine and Health.


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