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A family of actin-binding proteins with PDZ domains that are involved in control of various developmental processes through the regulation of cell shape. The original mouse mutation was designated ‘shroom’ (shrm), because the neural folds ‘mushroom’ outward and do not converge at the dorsal midline. The common feature is the Apx/Shrm domain 2 (ASD2) and shroom-related proteins are found in a wide range of species. Shroom 1 (852 aa) may affect microtubule architecture, shroom 2 (1616 aa) binds cortical actin and is expressed in cells that exhibit polarized growth, including vascular endothelial cells and epithelial cells. Shroom 3 (1986 aa) interacts with microfilament bundles and also γ-tubulin. Shroom 4 (1498 aa) may regulate the spatial distribution of myosin II.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1481537 Article on standardization of nomenclature in BMC Cell Biology (2006).

Subjects: Medicine and Health.

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