Progressive renal disease developing in 5–8% of patients with sickle-cell disease. Infarcts in the cortex can occur with sickle-cell crises and present with pain and haematuria. Acute or more insidious damage to the medulla will lead to a urinary concentrating defect and later to papillary necrosis and/or fibrosis. Occlusion of vessels within the glomerular capillary tuft leads to a secondary form of focal segmental glomerulosclerosis and can present with the nephrotic syndrome.
Subjects: Medicine and Health.