Overview

sigma receptor


Related Overviews

 

More Like This

Show all results sharing this subject:

  • Medicine and Health

GO

Show Summary Details

Quick Reference

Originally described as one of the opiate receptor subtypes but subsequently shown to be nonopioid receptors. Sigma-1 receptors have high to moderate affinities for (+)benzomorphans, many psychotrophic drugs, and neurosteroids such as dehydroepiandrosterone sulphate. Sigma-2 receptors, unlike sigma-1, are not coupled to Gi/o proteins and sigma-2 receptor agonists have been shown to induce cell death via both caspase-dependent and -independent pathways.

Subjects: Medicine and Health.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.