sigma receptor

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Originally described as one of the opiate receptor subtypes but subsequently shown to be nonopioid receptors. Sigma-1 receptors have high to moderate affinities for (+)benzomorphans, many psychotrophic drugs, and neurosteroids such as dehydroepiandrosterone sulphate. Sigma-2 receptors, unlike sigma-1, are not coupled to Gi/o proteins and sigma-2 receptor agonists have been shown to induce cell death via both caspase-dependent and -independent pathways.

Subjects: Medicine and Health.

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