(rapamycin) n. an immunosuppressant drug used to prevent rejection in kidney transplantation. Sirolimus was first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from Rapa Nui (the Polynesian name for Easter Island), hence the alternative name. Administered by mouth, it blocks the activation of B and T lymphocytes by interleukin 2 (IL-2). Trade name: Rapamune.
Subjects: Clinical Pharmacology and Therapeutics.