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(rapamycin) n. an immunosuppressant drug used to prevent rejection in kidney transplantation. Sirolimus was first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from Rapa Nui (the Polynesian name for Easter Island), hence the alternative name. Administered by mouth, it blocks the activation of B and T lymphocytes by interleukin 2 (IL-2). Trade name: Rapamune.

Subjects: Clinical Pharmacology and Therapeutics.

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