A subfamily of calcium-activated potassium channels (small conductance calcium-activated potassium channels) of which there are four members (SK1 (KCa2.1), SK2 (KCa2.2), SK3 (KCa2.3), and SK4 (KCa3.1), the products of genes KCNN1–4). The calcium sensitivity comes from association with calmodulin. Because they are activated when intracellular calcium levels rise they limit the firing frequency of neurons and other electrically excitable cells. SK channels are thought to be involved in synaptic plasticity. They are selectively inhibited by apamin and scyllatoxin.
Subjects: Medicine and Health.