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skeletrophin


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A RING finger-dependent ubiquitin ligase (mindbomb homologue 2, MIB2, 1013 aa), which targets the intracellular region of notch ligands. It has a dystrophin-like domain, five ankyrin repeats, interacts with α-actin, and is induced by the overexpression of truncated human SWI1 (SMARCF1), a subunit of the chromatin remodelling complex.

Subjects: Medicine and Health.


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