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1. An oncogene, ski (Sloan-Kettering Institute proto-oncogene), found in an avian carcinoma. The cellular form, c-ski, is a corepressor of Smad3 and regulates fibroblast proliferation.

2. Subtilisin/kexin isozyme-1 (SKI-1, site-1 protease, S1P), a Golgi proteinase mediating the proteolytic activation of the precursor to sterol-regulated element-binding proteins (SREBPs 1 and 2).

3. The homologue of Drosophila skinny hedgehog (SKI1, hedgehog acyltransferase, HHAT), an enzyme that catalyses N-terminal palmitoylation of hedgehog.

Subjects: Medicine and Health — Chemistry.


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