Proteins associated with the CDK2/cyclin A kinase complex (S-phase kinase-associated proteins) involved in regulating cell cycle progression; the complex includes a 19-kDa protein (p19, Skp1, 163 aa) and a 45-kDa protein (p45, Skp2, 424 aa). Skp1 is also a component of the SCF (Skp1-*cullin- F-box) ubiquitin ligase complex, in which Skp2 is also involved. The SCF complex regulates the function of NFκB. Skp2 can deregulate growth in vivo and may be involved in the pathogenesis of lymphomas.
Subjects: Medicine and Health.