A family of immunoglobulin superfamily receptors (signalling lymphocyte activation molecules) expressed by a wide range of immune cells. They interact with various signalling proteins through their cytoplasmic domains to coactivate immune responses in T and B cells. SLAM-associated proteins (SAPs) are adaptors with SH2 domains. SAP (128 aa) is T-cell-specific and blocks recruitment of Shp2, it is mutated in X-linked lymphoproliferative disease (XLP). A set of SLAM family receptors, including SLAM1 (CD150, 335 aa), SLAM4 (CD244, natural killer cell activation inducing ligand), and SLAM5 (CD84) among others, play important roles in innate and adaptive immunity.
Subjects: Medicine and Health.