somatic hypermutation

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'somatic hypermutation' can also refer to...

somatic hypermutation

somatic hypermutation

somatic cell hypermutation

somatic cell hypermutation

Directed molecular evolution by somatic hypermutation

Checkpoint kinase 1 negatively regulates somatic hypermutation

Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation

Strand bias in Ig somatic hypermutation is determined by signal sequence within the variable region

Ig gene somatic hypermutation in mice defective for DNA polymerase δ proofreading

Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D)

Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice

Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation

Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination

IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

Author's reply: Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

Overexpression of human DNA polymerase μ (Pol μ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate

The PU.1 and NF-EM5 binding motifs in the Igκ 3′ enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vκ gene

BCR signal through α4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation


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A mechanism by which activated B cells can generate antibodies of increased specificity and with improved antigen binding over the course of an adaptive immune response. Special adaptations of these cells give rise to a relatively high rate of enzyme-induced base changes to the DNA of genes encoding the variable regions of both heavy and light chains of the antibody molecules. Such mutations are confined to clones of B cells generated by a T-cell-mediated response to the presence of specific antigen (see helper T cell) and do not affect germ-line cells, so cannot be inherited. Over the course of several weeks, B cells that accumulate beneficial mutations producing better antigen binding receive signals that promote their proliferation, whereas their counterparts with deleterious mutations can no longer bind antigen and die. Consequently, the efficiency of antigen binding of the B-cell population, and hence the overall effectiveness of the antibody response, increase over time. Compare somatic recombination.

Subjects: Biological Sciences.

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