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1. A guanine nucleotide exchange factor (GEF, 1336 aa) that is a positive regulator of ras and the human homologue of Drosophila son-of-sevenless. Binds to the SH3 domain of grb2. A family of related proteins includes vav, C3G, Ost, NET1, Ect2, RCC1, tiam, RalGDS, and Dbl.

2. See SOS system.

Subjects: Chemistry — Medicine and Health.

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