One of the AAA family of ATPases that is mutated in autosomal dominant hereditary spastic paraplegia type 4 (SPG4). It interacts with microtubules and probably has a role in microtubule dynamics. It is highly homologous to the microtubule-severing protein katanin and there is a domain of ~80 aa found also in spartin. Binds to atlastin.
Subjects: Medicine and Health.