Overview

spastin


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One of the AAA family of ATPases that is mutated in autosomal dominant hereditary spastic paraplegia type 4 (SPG4). It interacts with microtubules and probably has a role in microtubule dynamics. It is highly homologous to the microtubule-severing protein katanin and there is a domain of ~80 aa found also in spartin. Binds to atlastin.

Subjects: Medicine and Health.


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