Overview

SPAK


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A serine/threonine kinase (Ste20/SPS-1-related proline, alanine-rich kinase, 547 aa) that will phosphorylate and activate NKCC1 (Na+-K+-2Cl cotransporter-1). SPAK and OSR1 (oxidative stress-responsive kinase-1), are activated by WNKs.

Subjects: Medicine and Health.


Reference entries

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