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spectrosome


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A prominent spectrin-rich, spherical mass found in the cytoplasm of germ line stem cells (q.v.) and cytoblasts (q.v.) in the Drosophila ovary. The spectrosome is rich in cytoskeletal proteins such as actin (q.v.), α- and β-spectrin, the adducin-like Hts protein, and ankyrin (q.v.). This organelle is though to be a precursor of the fusome (q.v.) and to anchor the mitotic spindle during germ line stem cell and cystoblast divisions. hts and α- spectrin mutations eliminate spectrosome and fusome formation and result in aberrant mitotic spindle orientation during germ line stem cell and cystoblast/cystocyte divisions. See adducin, ankyrin, cystocyte divisions, hu-li tai shao (hts), spectrin.

Subjects: Genetics and Genomics.


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