spindle poison

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Any compound that binds to certain molecular components of spindles and causes them to malfunction. A subset of the spindle poisons, notably paclitaxel, vinblastine, and vincristine (all of which see), have turned out to be potent anticancer drugs. Others like colchicine and podophyllin (both of which see) have been clinical failures. See tubulin.

Subjects: Genetics and Genomics.

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